Bioinformatics Assistant Laboratory of Genome Architecture and Dynamics

Organization Overview

The Laboratory of Genome Architecture and Dynamics studies how the three-dimensional architecture of the genome reflects and regulates DNA-based processes,with a focus on short-range contacts and biophysical mechanisms of transcriptional silencing. By developing integrative models of the molecular interactions that regulate access to the genome,we hope to understand and rationally manipulate changes in chromatin architecture and gene expression during differentiation and cell reprogramming,in transitions between growth,quiescence,and senescence,and in the dysregulated cellular states found in cancer. We use mammalian primary cells and cell lines as model systems. Our approaches include sequencing-based genomic assays,biochemistry,microscopy,and modeling. We are also actively developing new methods for probing chromatin architecture in intact cells.

Overview

The Bioinformatics Assistant will maintain the Risca Lab's bioinformatics infrastructure and participate in data analysis and/or running simulations for chromatin organization and multi-omics projects.

Responsibilities

Responsibilities include

• Perform data analysis and/or simulations related to chromatin structure and multi-omics projects

• Install software as needed on lab's high-performance computing cluster account

• Maintain lab's bioinformatics pipelines for basic sequencing data alignment

• Back up lab data and maintains lab metadata databases (with lab manager)

• Perform related duties & responsibilities as assigned/requested

Qualifications

Required

• Bachelor's degree in computer science, mathematics or applied mathematics, life sciences, or physical science

• Proficient in at least one programming language such as python

• Undergraduate research experience or documentation of extensive computational/bioinformatics course work

Preferred

• Proficiency in Python and some familiarity with R

• Familiarity with DNA sequencing-based bioinformatics OR with simulation methods (Monte Carlo, BD, MD)

• Statistics or probability course

The Rockefeller University does not discriminate in employment on the basis of race, color, religion, sex (including pregnancy, gender identity), national origin, political affiliation, sexual orientation, marital status, disability, genetic information, age, membership in an employee organization, retaliation, parental status, military service or other non-merit factor. All qualified applicants will receive consideration for employment without regard to the characteristics listed above.

The salary of the finalist selected for this role will be set based on various factors, including but not limited to organizational budgets, qualifications, experience, education, licenses, specialty, and training. The hiring range provided represents The Rockefeller University's good faith and reasonable estimate of the range of possible compensation at the time of posting.

Compensation Range: Min

USD $48,000.00/Yr.

Compensation Range: Max

USD $56,000.00/Yr.